A review on the production and evaluation of bioactive peptides on human and animal health

Document Type : Scientific-Extensional Article

Authors

1 B.Sc. Student, Department of Food Science and Technology, Faculty of Agriculture at the University of Kurdistan, Sanandaj, Iran

2 Ph.D. Student, Department of Food Science and Technology, Faculty of Agriculture at the University of Tabriz, Tabriz, Iran

Abstract

Bioactive peptides are specific protein derivatives whose specific activities are based on the composition and sequence of amino acids in their chemical structure. These compounds can play an important role in human health by affecting the digestive system, endocrine system, cardiovascular system, immune system, and nervous system. Bioactive peptides are a new generation of biologically active regulators and play an effective role in the prevention and treatment of various diseases. It has also been shown that these compounds can preserve food quality by maintaining oxidation and microbial spoilage. The importance and properties of bioactive peptides have encouraged the scientific community, especially researchers in the food science and industry, to acquire and develop new food additives and functional products based on these peptides. There are many sources for the production of peptides from proteins, such as animal and plant sources. In the meantime, milk proteins have been proposed as one of the most important sources that can be used in this field. In the present study, the latest findings obtained in recent years regarding the production, identification, and properties of bioactive peptides are discussed.

Keywords

References

ربیعی، ث.، نیکو، م.، رضایی، م.، و رفیعیان کوپایی، م. (۱۳۹۷). "مروری بر اثرات پپتیدهای زیست فعال آبزیان در مدل­‌های جانوری و انسان." مجله فیزیولوژی و فارماکولوژی ایران، ۴(۲)، ۲۰۱-۲۱۳.
کاوه، ش.، صادقی ماهونک، ع.، قربانی، م.، جعفری، م.،و  سرابندی، خ. (۱۳۹۷). "بهینه سازی تولید پپتیدهای آنتی‌­اکسیدان توسط هیدرولیز آنزیمی پروتئین دانه شنبلیله." علوم و صنایع غذایی، ۱۵(۸۴)، ۷۵-۸۸.
میردامادی، س.، سلیمان زاده، ن.، میرزایی، م.، و مطهری، پ. (۱۳۹۶). "پپتیدهای زیست فعال: فرآیند تولید، اثرات سلامت بخشی و کاربرد به عنوان افزودنی‌­های طبیعی در تولید غذاهای فراسودمند." بهداشت مواد غذایی، ۷(۱)، ۱-۱۹.
میرزایی، س.،گراوند، ف.، و کرمی نیا، ا. (۱۳۹۳). "نحوه تولید و کاربردهای پپتیدهای زیست فعال." اولین همایش ملی میان وعده­‌های غذایی، پژوهشکده علوم و فناوری مواد غذایی.
Agyei, D., and Danquah, K.M. (2011). “Industrial-scale manufacturing of pharmaceutical-grade bioactive peptides.” Biotechnology Advances, 29(3), 272-277.
Agyei, D., and Danquah, K.M. (2012). “Rethinking food-derived bioactive peptides for antimicrobial and immunomodulatory activities.” Trends in Food Science & Technology, 23(2), 62-69.
Aluko, R.E. (2012). “Bioactive peptides. Functional foods and nutraceuticals.” Springer Verlag, New York.
Boukil, A., Suwal, S., Chamberland, J., Poulioti, Y., and Doyen, A. (2018). “Ultrafiltration performance and recovery of bioactive peptides after fractionation of tryptic hydrolysate generated from pressure-treated β-lactoglobulin.” Journal of Membrane Science, 556, 42-53.
Chakrabarti, S., and Wu, J. (2016). “Bioactive peptides on endothelial function.” Food Science and Human Wellness, 5(1), 1-7.
Chaves-López, C., Serio, A., Paparella, A., Martuscelli, M., Corsetti, A., and et al. (2014). “Impact of microbial cultures on proteolysis and release of bioactive peptides in fermented milk.” Food Microbiology, 42, 117-121.
Dionysius, D.A., and Milne, J.M. (1997). “Antibacterial peptides of bovine lactoferin: purification and characterization.” Journal of Dairy Science, 80, 667-674.
Fosgerau, K., and Ohshima, T. (2015). “Peptide therapeutics: current status and future directions.” Drug Discovery Today, 20, 122–128.
Guaadaoui, A., Benaicha, S., Elmajdoub, N., Bellaoui, M., and Hamal, A. (2014). “What is a bioactive compound? A combined definition for a preliminary consensus.” International Journal of Nutrition and Food Sciences, 3(3), 174-179.
Harnedy, P.A., and FitzGerald, R.J. (2012). “Bioactive peptides from marine processing waste and shellfish: A review.” Journal of Functional Foods, (4), 6-24.
Lau, J.L., and Dunn, M.K. (2018). “Therapeutic peptides: historical perspectives current development trends and future directions.” Bioorganic & Medicinal Chemistry Journal, 26, 2700–2707.
Miquel, E., Gomez, J.A., Aleqria, A., Barbera, R., Farre, R., and et al. (2005). “Identification of casein phosphopeptides released after simulated digestion of milk based infant formulas.” Journal of Agricultural and Food Chemistry, 53, 3426 -3433
Mohanty, D.P., Mohapatra, S., Misra, S., and Sahu, P.S. (2016). “Milk derived bioactive peptides and their impact on human health – A review.” Saudi Journal of Biological Sciences, 23(5), 577-583.
Nikoo, M., and Benjakul, S. (2015). “Potential application of seafood-derived peptides as bifunctional ingredients antioxidant–cryoprotectant: A review.” Journal of Functional Foods, 10, 753-764.
Panyayai, T., Ngamphiw, C., Tongsima, S., Mhuantong, W., Limsripraphan, W., and et al. (2019). “FeptideDB: A web application for new bioactive peptides from food protein.” Heliyon, 5(7), 1-8.
Sanchez, A., and Vazquez, A. (2017). “Bioactive peptides: A review.” Food Quality and Safety, 1, 29-46.
Sarmadi, B.H., and Ismail, A. (2010). “Antioxidative peptides from food proteins: a review.” Peptides, 31, 1949-1956
Shahidi, F., and Zhong, Y. (2008). “Bioactive Peptides.” Journal of AOAC International, 91, 914-931.
Singh, B.P., Vij, S., and Hati, S. (2014). “Functional significance of bioactive peptides derived from soybean.” Peptides, 54, 171-179.
Teschemacher, H., Koch, G., and Brantl, V. (1997). “Milk protein-derived opioid receptor ligands.” Biopolymers, 43, 99-117.
Tüysüz, B., Cakir, O., and Sahin, E. (2019). “Bioactive Peptides: Formation and Impact Mechanisms.” 3rd International Conference on Advanced Engineering Technologies, 19-21.
Walther, B., and Sieber, R. (2011). “Bioactive proteins and peptides in foods.” International Journal of Vitamin and Nutrition Research, 81, 181-192.
Zhang, X., Chen, F., and Wang, M. (2015). “Bioactive Substances of Animal Origin.” Handbook of Food Chemistry, 1-21.

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