Evaluation of GDF9, BMP15 and BMPR-IB Twin Genes in Some Sheep

Document Type : Scientific-Extensional Article

Authors

1 M.Sc. Student of Animal Breeding and Genetics, Department of Animal Science, College of Agriculture and Natural Resources at the University of Tehran

2 Professor of Animal Breeding and Genetics, Department of Animal Science, College of Agriculture and Natural Resources at the University of Tehran

Abstract

In our country, in recent decades extensive studies have been done to increase the efficiency of reproductive traits of sheep in the country. The effect of large genes was one of the measures taken in this regard. Genes GDF9, BMP15, and BMPR-IB are members of the TGFβ (Transforming Growth Factorβ) family, which have a biologically active system that together constitutes a significant portion of the variance of the multi-breeding trait in sheep.GDF9 gene is autosomal and has an additive effect on ovulation rate, this gene on chromosome 5 only results in heterozygous ovulation and the homozygous genotype for this allele is sterile. The Growth Differentiation Factor (GDF) is called the Fec G. BMP15 gene is sex-linked and is located on the X chromosome. This gene belongs to the category of bone morphogenic protein (BMP) and called Fec X. booroola gene (BMPR-IB) or (ALK6) is autosomal and the first large gene was the effect reported on increased fertility and called Fec B.The study of BMP15 and GDF9 genes in Iranian sheep indicates the absence of large effector mutations that lead to sterility in the homozygous state.

Keywords

References

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