Application of liposomes in the sperm cryopreservation

Document Type : Scientific-Extensional Article

Authors

1 Ph.D. student of Animal Physiology, Department of Animal Science, College of Agriculture and Natural Resources at the University of Tehran

2 Professor, University College of Agriculture & Natural Resources, University of Tehran, Karaj, Iran 4 Professor, IBB Center, University of Tehran, Tehran, Iran

3 Associate Professor, Department of Animal Science, University College of Agriculture and Natural Resources, University of Tehran, Karaj, Iran

4 Professor, IBB Center, University of Tehran, Tehran, Iran

5 Assistant Professor of Animal Physiology, Tarbiat Modares University, Department of Animal science, Tehran, Iran

Abstract

The aim of this study was to evaluate the use of soybean lecithin liposomes in cryopreservation of animal sperm. Liposomes are bilayer phospholipid membranes and they are similar to cell membranes. Liposomes can protect the sperm membrane by sperm coating or phospholipid transferring during the freeze-thawing process. Researches have shown the possibility of using liposomes from different aspects, including animal reproduction technology, a model of sperm cell membrane, a carrier for unstable compounds and a sperm cryoprotectant. Liposomes are also used to treat diseases such as cancer. Also, liposomes can encapsulate hydrophilic and hydrophobic antioxidants because of their two lipid layers. The liposome bilayer phospholipids are a place for the encapsulation of hydrophobic drugs. Encapsulation of drugs in this part decreases their movement and lead to their slow releasing. Therefore, liposomes can have a protective role for sperm during the freezing and thawing process.

Keywords

References

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